Structure of PDB 4pmw Chain A Binding Site BS02

Receptor Information
>4pmw Chain A (length=691) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG
VVARNRALNGDLVVVKLLPEKSAKVVYILEKKHSRAATGILKLLFKKYAL
FSPSDHRVPRIYVPLKDCPQDFMTRPKDFANTLFICRIIDWKEDCNFALG
QLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQSLPWTIPPDE
VGKRRDLRKDCIFTIDPSTARDLNDALACRRLTDGTFEVGVHIADVSYFV
PEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVI
WKLTPEGKILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPEEELPPIS
PEHSVEEVHQAVLNLHSIAKQLRRQRFVDGALRLDQLKLAFTLDHETGLP
QGCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQALLRRHPPPQTKM
LSDLVEFCDQMGLPMDVSSAGALNKSLTKTFGDDKYSLARKEVLTNMYSR
PMQMALYFCSGMLQDQEQFRHYALNVPLYTHFTSPIRRFADVIVHRLLAA
ALGYSEQPDVEPDTLQKQADHCNDRRMASKRVQELSIGLFFAVLVKESGP
LESEAMVMGVLNQAFDVLVLRFGVQKRIYCNALALRSYSFQKVGKKPELT
LVWEPDDLEEEPTQQVITIFSLVDVVLQAEATALKYSAILK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4pmw Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4pmw Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		D381 D390
Binding residue
(residue number reindexed from 1)		D216 D225
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D381 D387 N389 D390 Y492 R702
Catalytic site (residue number reindexed from 1) D216 D222 N224 D225 Y327 R537
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4pmw, PDBe:4pmw, PDBj:4pmw
PDBsum4pmw
PubMed25119025
UniProtQ8CI75|DI3L2_MOUSE DIS3-like exonuclease 2 (Gene Name=Dis3l2)

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