Structure of PDB 4otp Chain A Binding Site BS02

Receptor Information
>4otp Chain A (length=236) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKK
TWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQ
LSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQ
SVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHEN
MDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4otp Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4otp Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N329 X341
Binding residue
(residue number reindexed from 1)		N135 X147
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.3.-
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4otp, PDBe:4otp, PDBj:4otp
PDBsum4otp
PubMed24948609
UniProtQ9BRS2|RIOK1_HUMAN Serine/threonine-protein kinase RIO1 (Gene Name=RIOK1)

[Back to BioLiP]