Structure of PDB 4ofa Chain A Binding Site BS02

Receptor Information
>4ofa Chain A (length=142) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPS
AEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGI
GKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
Ligand information
Receptor-Ligand Complex Structure
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PDB4ofa Structure of MBD4 bound to G:T mispair DNA
Resolution1.55 Å
Binding residue
(original residue number in PDB)		R468 K472 K504 P505 G507 L508 Y509 D510 L511
Binding residue
(residue number reindexed from 1)		R31 K35 K67 P68 G70 L71 Y72 D73 L74
Enzymatic activity
Enzyme Commision number 3.2.2.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4ofa, PDBe:4ofa, PDBj:4ofa
PDBsum4ofa
PubMed
UniProtO95243|MBD4_HUMAN Methyl-CpG-binding domain protein 4 (Gene Name=MBD4)

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