Structure of PDB 4o6j Chain A Binding Site BS02

Receptor Information

>4o6j Chain A (length=213) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RSVTEEDYLKIIQELVLYKGYATLADISRSLNVKRQSVRDEINHLISLSM
AEKIERGKYRLTPSGDREANRFLRKHRTAEILLSRCIGIPWERVDEEAMG
IEHGMTEEIIQRTIERFGVDRCPHGNPIPDPEGNVEPVADVRITSLLPDS
TARISRIVYETDDILHFLALNGLIPGKDIKIESVKDTVRVLVDGRSIEIP
TDIAMAIMVTVDD

Ligand information

InChI=1S/Fe/q+2

CWYNVVGOOAEACU-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Fe+2]
CACTVS 3.341	[Fe++]

Formula

Name

FE (II) ION

PDB chain

4o6j Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4o6j Structural analysis and insight into metal-ion activation of the iron-dependent regulator from Thermoplasma acidophilum.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	H82 E86 D101 E166
Binding residue (residue number reindexed from 1)	H76 E80 D95 E160
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	R73 I95 P96 R99
Catalytic site (residue number reindexed from 1)	R67 I89 P90 R93
Enzyme Commision number	?

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0046872	metal ion binding
GO:0046914	transition metal ion binding
GO:0046983	protein dimerization activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4o6j, PDBe:4o6j, PDBj:4o6j
PDBsum	4o6j
PubMed	24816097
UniProt	Q9HJU1

[Back to BioLiP]