Structure of PDB 4o3m Chain A Binding Site BS02

Receptor Information
>4o3m Chain A (length=613) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILM
PTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTG
DKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLL
ARFVIDEAHRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKIL
RPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSR
RECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIA
FGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDV
TRLKRLIMMEKDHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFN
PDFCKKHPDVSCDNCCKYKTRDVTDDVKSIVRFVQEHSPSGRFTMNMLVD
IFLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQ
AIAYVMLGNKAQTVLNGNLKVDFMETENKVSQREEMVKKCLGELTEVCKS
LGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEV
ISVLQKYSEWTSP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4o3m Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L896 S897 R898 A920 T946 I947 A948 R1000 R1003 L1004 M1007 E1008 S1121 K1122 N1164 D1165 Q1166
Binding residue
(residue number reindexed from 1)		L248 S249 R250 A272 T298 I299 A300 R352 R355 L356 M359 E360 S455 K456 N498 D499 Q500
Binding affinityPDBbind-CN: Kd=12.8nM
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4o3m, PDBe:4o3m, PDBj:4o3m
PDBsum4o3m
PubMed24816114
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

[Back to BioLiP]