Structure of PDB 4nzv Chain A Binding Site BS02

Receptor Information
>4nzv Chain A (length=329) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHVINLKELKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVEEA
EKREVDLILLTGDLLHSRNNPSVVALHDLLDYLKRMMRTAPVVVLPGNHD
WKGLKLFGNFVTSISSDITFVMSFEPVDVEAKRGQKVRILPFPYPDESEA
LRKNEGDFRFFLESRLNKLYEEALKKEDFAIFMGHFTVEGLAGYAGIEQG
REIIINRALIPSVVDYAALGHIHSFREIQKQPLTIYPGSLIRIDFGEEAD
EKGAVFVELKRGEPPRYERIDASPLPLKTLYYKKIDTSALKSIRDFCRNF
PGYVRVVYEEDSGILPDLMGEIDNLVKIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4nzv Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4nzv DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Resolution1.901 Å
Binding residue
(original residue number in PDB)		D14 H16 D58 H216 H218
Binding residue
(residue number reindexed from 1)		D19 H21 D63 H221 H223
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0006259 DNA metabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4nzv, PDBe:4nzv, PDBj:4nzv
PDBsum4nzv
PubMed24316220
UniProtQ9X1X0|MRE11_THEMA DNA double-strand break repair protein Mre11 (Gene Name=mre11)

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