Structure of PDB 4nyz Chain A Binding Site BS02

Receptor Information

>4nyz Chain A (length=460) Species: 12107 (Mengo virus)

GALERLPDGPRIHVPRKTALRPTVARQVFQPAFAPAVLSKFDPRTDADVD
EVAFSKHTSNQETLPPVFRMVAREYANRVFALLGRDNGRLSVKQALDGLE
GMDPMDKNTSPGLPYTTLGMRRTDVVDWETATLIPFAAERLEKMNNKDFS
DIVYQTFLKDELRPIEKVQAAKTRIVDVPPFEHCILGRQLLGKFASKFQT
QPGLELGSAIGCDPDVHWTAFGVAMQGFERVYDVDYSNFDSTHSVAVFRL
LAEEFFSEENGFDPLVKDYLESLAISKHAYEEKRYLITGGLPSGCAATSM
LNTIMNNIIIRAGLYLTYKNFEFDDVKVLSYGDDLLVATNYQLNFDRVRT
SLAKTGYKITPANKTSTFPLESTLEDVVFLKRKFKKEGPLYRPVMNREAL
EAMLSYYRPGTLSEKLTSITMLAVHSGKQEYDRLFAPFREVGVIVPTFES
VEYRWRSLFW

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4nyz Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4nyz The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): K159 E161 R163 T173 R174
• Binding residue (residue number reindexed from 1): K159 E161 R163 T173 R174
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4nyz, PDBe:4nyz, PDBj:4nyz
• PDBsum: 4nyz
• PubMed: 24600002
• UniProt: P12296|POLG_ENMGO Genome polyprotein