Structure of PDB 4npk Chain A Binding Site BS02

Receptor Information
>4npk Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRV
IKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEV
EKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNVSNLDKVLTDIKADGLSS
ALLILYLDSARNLPSSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTF
FIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNS
GPNSTIKMKIALRVLHLEK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4npk Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4npk Structure and ca(2+)-binding properties of the tandem c2 domains of e-syt2.
Resolution2.552 Å
Binding residue
(original residue number in PDB)		K400 D401 D460 D462 D467
Binding residue
(residue number reindexed from 1)		K21 D22 D81 D83 D88
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006869 lipid transport
GO:0061817 endoplasmic reticulum-plasma membrane tethering

View graph for
Biological Process
External links
PDB RCSB:4npk, PDBe:4npk, PDBj:4npk
PDBsum4npk
PubMed24373768
UniProtA0FGR8|ESYT2_HUMAN Extended synaptotagmin-2 (Gene Name=ESYT2)

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