Structure of PDB 4no4 Chain A Binding Site BS02

Receptor Information
>4no4 Chain A (length=134) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ACGLVASNLNAKPGECLKVRGELAPDAKSFVLNLGKDSNNLCLHFNPRFN
AHGDANTIVCNSKDDGTWGTEQRETAFPFQPGSITEVCITFDQADLTIKL
PDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE
Ligand information
Ligand IDGAL
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
FormulaC6 H12 O6
Namebeta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBLCHEMBL300520
DrugBank
ZINCZINC000002597049
PDB chain4no4 Chain G Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4no4 Crystal Structure of Galectin-1 L11A mutant
Resolution1.399 Å
Binding residue
(original residue number in PDB)		H45 R49 N62 W69 E72
Binding residue
(residue number reindexed from 1)		H44 R48 N61 W68 E71
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0030395 lactose binding
GO:0042802 identical protein binding
GO:0043236 laminin binding
Biological Process
GO:0002317 plasma cell differentiation
GO:0006915 apoptotic process
GO:0009410 response to xenobiotic stimulus
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0031295 T cell costimulation
GO:0034120 positive regulation of erythrocyte aggregation
GO:0035900 response to isolation stress
GO:0043065 positive regulation of apoptotic process
GO:0045185 maintenance of protein location
GO:0045445 myoblast differentiation
GO:0046598 positive regulation of viral entry into host cell
GO:0048678 response to axon injury
GO:0050729 positive regulation of inflammatory response
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0098609 cell-cell adhesion
GO:2001200 positive regulation of dendritic cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:1990724 galectin complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4no4, PDBe:4no4, PDBj:4no4
PDBsum4no4
PubMed
UniProtP11762|LEG1_RAT Galectin-1 (Gene Name=Lgals1)

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