Structure of PDB 4nmn Chain A Binding Site BS02

Receptor Information

>4nmn Chain A (length=425) Species: 224324 (Aquifex aeolicus VF5)

PCDESAERAVLGSMLEDPENIPLVLEYLKEEDFCIDEHKLLFRVLTNLWS
EYGNKLDFVLIKDHLEKKNLLQIDWLEELYEEAVSPDTLEEVCKIVKQRS
AQRAIIQLGIELIHKGKENKDFHTLIEEAQSRIFSIAESSTQFYHVKDVA
EEVIELIYKFKSSDRLVTGLPSGFTELDLKTTGFHPGDLIILAARPGMGK
TAFMLSIIYNLAKDEGKPSAVFSLEMSKEQLVMRLLSMMSEVPLFKIRSG
SISNEDLKKLEASAIELAKYDIYLDDTPALTTTDLRIRARKLRKEKEVEF
VAVDYLQLLRPPVRKSPRQEEVAEVSRNLKALAKELRIPVMALAQLSREV
EKRSDKRPQLADLRESGQIEQDADLILFLHRPEYYTKKPNEQGIAEVIIA
KQRQGPTDIVKLAFIKEYTKFANLE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4nmn Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4nmn Nucleotide and partner-protein control of bacterial replicative helicase structure and function.
• Resolution: 3.301 Å
• Binding residue (original residue number in PDB): T213 E237
• Binding residue (residue number reindexed from 1): T201 E225
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006268 DNA unwinding involved in DNA replication
• GO:0006269 DNA replication, synthesis of primer
• GO:0032508 DNA duplex unwinding

Cellular Component

• GO:0005829 cytosol
• GO:1990077 primosome complex

External links

• PDB: RCSB:4nmn, PDBe:4nmn, PDBj:4nmn
• PDBsum: 4nmn
• PubMed: 24373746
• UniProt: O67450