Structure of PDB 4ni9 Chain A Binding Site BS02

Receptor Information
>4ni9 Chain A (length=144) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHRQPLTSSERIDKQIRYILDGISALRKETNLNLPKMAEKDGCFQSGFNE
ETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKA
PTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
Ligand information
Receptor-Ligand Complex Structure
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PDB4ni9 Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		S107 S108 E109 E110 Q111
Binding residue
(residue number reindexed from 1)		S77 S78 E79 E80 Q81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
Biological Process
GO:0006955 immune response
GO:0030154 cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ni9, PDBe:4ni9, PDBj:4ni9
PDBsum4ni9
PubMed24415767
UniProtP05231|IL6_HUMAN Interleukin-6 (Gene Name=IL6)

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