Structure of PDB 4n6h Chain A Binding Site BS02

Receptor Information

>4n6h Chain A (length=408) Species: 562,9606

DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDK
SPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAY
IQKYLGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKM
KTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY
NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIIT
VCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIF
VIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFR
QLCRKPCG

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 4n6h Chain A Residue 1220

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4n6h Molecular control of delta-opioid receptor signalling.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D95 N131 S135
• Binding residue (residue number reindexed from 1): D165 N201 S205
• Annotation score: 3

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004985 G protein-coupled opioid receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0038046 G protein-coupled enkephalin receptor activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:4n6h, PDBe:4n6h, PDBj:4n6h
• PDBsum: 4n6h
• PubMed: 24413399
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P41143|OPRD_HUMAN Delta-type opioid receptor (Gene Name=OPRD1)