Structure of PDB 4n5s Chain A Binding Site BS02

Receptor Information
>4n5s Chain A (length=542) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPKALEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPY
KALRDLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEG
VARRYGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSA
VLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQ
LERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELT
KLKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTP
LGQRIRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIH
TETASWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEA
QAFIERYFQSFPKVRAWLEKTLEEGRRRGYVETLFGRRRYVPDLEARVKS
VREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVL
EAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n5s A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 A570 T571 R573 S575 S576 S577 D578 N580 G668 Y671 M673 S674 R677 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N194 N196 S197 S254 T255 T280 A281 T282 R284 S286 S287 S288 D289 N291 G379 Y382 M384 S385 R388 R439 R457 M458 N461 Q465
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4n5s, PDBe:4n5s, PDBj:4n5s
PDBsum4n5s
PubMed25537790
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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