Structure of PDB 4n56 Chain A Binding Site BS02

Receptor Information
>4n56 Chain A (length=494) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALR
DLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARR
YGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAH
MEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERV
LFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKS
TYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQR
IRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETA
AKTINFGVLYGFPKVRAWLEKTLEEGRRRGYVETLFGRRRYVPDLEARVK
SVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELV
LEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
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PDB4n56 A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 Q489 S543 T544 T569 A570 T571 R573 S575 S576 S577 D578 N580 F667 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N190 N192 S193 Q196 S250 T251 T276 A277 T278 R280 S282 S283 S284 D285 N287 F356 R390 R408 M409 N412 Q416
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4n56, PDBe:4n56, PDBj:4n56
PDBsum4n56
PubMed25537790
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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