Structure of PDB 4mbb Chain A Binding Site BS02

Receptor Information
>4mbb Chain A (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLGSNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSP
LDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVPD
DETIFKFKHAVNGFLKENKDNDKLIGVHSTHGLNRTGYLICRYLIDVEGV
RPDDAIELFNRCRGHCLERQNYIEDLQNGPIRKN
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain4mbb Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4mbb Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase.
Resolution1.849 Å
Binding residue
(original residue number in PDB)		S152 T153 H154 L156 N157 R158
Binding residue
(residue number reindexed from 1)		S129 T130 H131 L133 N134 R135
Annotation score3
Enzymatic activity
Enzyme Commision number 3.1.3.-
Gene Ontology
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Biological Process
External links
PDB RCSB:4mbb, PDBe:4mbb, PDBj:4mbb
PDBsum4mbb
PubMed24447265
UniProtO75319|DUS11_HUMAN RNA/RNP complex-1-interacting phosphatase (Gene Name=DUSP11)

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