Structure of PDB 4m8o Chain A Binding Site BS02

Receptor Information
>4m8o Chain A (length=1126) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQEVTTNQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDES
RVNDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSN
QLFEARKLLRPILQDNANNNVQRNIYNVKVDAKHLIEDIREYDVPYHVRV
SIDKDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDS
AVDQIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNEN
DEVALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIG
FAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIE
LDPELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLN
PDETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETY
VGGHVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSS
VDKVTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNR
LQPDSIKAERDCASCTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFP
NKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREA
IVCQRENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAK
KMIVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQM
ARALVERVGRPLELDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSML
NYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKE
EGKGIKKRYAVFNEDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGD
TLEGCYSAVASVCNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYE
GQKSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVA
IFSADIPIKRSFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITI
PAALQGVSNPVPRVEHPDWLKRKIAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4m8o Structural basis for processive DNA synthesis by yeast DNA polymerase epsilon.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 G555 G556 R686 S829 G832 M835 R836 K837 I965 K966 K967 R988 K1063 V1102 T1103 Y1145 R1149 K1156
Binding residue
(residue number reindexed from 1)		K457 G458 T459 G460 T461 T499 Y500 G502 G503 R626 S769 G772 M775 R776 K777 I905 K906 K907 R928 K1003 V1042 T1043 Y1085 R1089 K1096
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4m8o, PDBe:4m8o, PDBj:4m8o
PDBsum4m8o
PubMed24292646
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

[Back to BioLiP]