Structure of PDB 4m83 Chain A Binding Site BS02

Receptor Information
>4m83 Chain A (length=393) Species: 1890 (Streptomyces antibioticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHIAMFSIAAHGHVNPSLEVIRELVARGHRVTYAIPPVFADKVAATGARP
VLYHSTLPGPDADPEAWGSTLLDNVEPFLNDAIQALPQLADAYADDIPDL
VLHDITSYPARVLARRWGVPAVSLSPNLVAWKGYEEEVAEPMWREPRQTE
RGRAYYARFEAWLKENGITEHPDTFASHPPRSLVLIPKALQPHADRVDED
VYTFVGACQGDRAEEGGWQRPAGAEKVVLVSLGSAFTKQPAFYRECVRAF
GNLPGWHLVLQIGRKVTPAELGELPDNVEVHDWVPQLAILRQADLFVTHA
GAGGSQEGLATATPMIAVPQAVDQFGNADMLQGLGVARKLATEEATADLL
RETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAELPA
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain4m83 Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4m83 The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity.
Resolution1.698 Å
Binding residue
(original residue number in PDB)		G239 S240 A241 W289 V290 Q292 H305 G309 G310 E313
Binding residue
(residue number reindexed from 1)		G233 S234 A235 W283 V284 Q286 H299 G303 G304 E307
Annotation score4
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4m83, PDBe:4m83, PDBj:4m83
PDBsum4m83
PubMed
UniProtQ53685|OLED_STRAT Oleandomycin glycosyltransferase (Gene Name=oleD)

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