Structure of PDB 4lx9 Chain A Binding Site BS02

Receptor Information

>4lx9 Chain A (length=157) Species: 273057 (Saccharolobus solfataricus P2)

DFTLRNARMDDIDQIIKINRLTLPENYPYYFFVEHLKEYGLAFFVAIVDN
SVVGYIMPRIEWGFSNIKQLPSLVRKGHVVSIAVLEEYRRKGIATTLLEA
SMKSMKNDYNAEEIYLEVRVSNYPAIALYEKLNFKKVKVLKGYYADGEDA
YLMARPL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4lx9 Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4lx9 Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog.
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): H137 E176
• Binding residue (residue number reindexed from 1): H78 E117
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.255: N-terminal amino-acid N(alpha)-acetyltransferase NatA.
  2.3.1.258: N-terminal methionine N(alpha)-acetyltransferase NatE.

Gene Ontology

Molecular Function

• GO:0004596 peptide alpha-N-acetyltransferase activity
• GO:0008080 N-acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0046872 metal ion binding
• GO:0120518 peptide-methionine-alpha-N-acetyltransferase activity

Biological Process

• GO:0006474 N-terminal protein amino acid acetylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0031415 NatA complex

External links

• PDB: RCSB:4lx9, PDBe:4lx9, PDBj:4lx9
• PDBsum: 4lx9
• PubMed: 23959863
• UniProt: Q980R9|NAT_SACS2 N-alpha-acetyltransferase (Gene Name=ard1)