BioLiP

Receptor Information

>4lw3 Chain A (length=242) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DGASVHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRF
RFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIA
GPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIR
DAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKT
GLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS

Ligand ID

GDU

InChI

InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/t5-,6-,8+,9-,10+,11-,12-,13-,14-/m1/s1

InChIKey

HSCJRCZFDFQWRP-ABVWGUQPSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)O[P@@](=O)(O)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O
CACTVS 3.341	OC[CH]1O[CH](O[P](O)(=O)O[P](O)(=O)OC[CH]2O[CH]([CH](O)[CH]2O)N3C=CC(=O)NC3=O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341	OC[C@H]1O[C@H](O[P@@](O)(=O)O[P@@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O)[C@H](O)[C@@H](O)[C@H]1O
ACDLabs 10.04	O=P(OC1OC(C(O)C(O)C1O)CO)(O)OP(=O)(O)OCC3OC(N2C=CC(=O)NC2=O)C(O)C3O
OpenEye OEToolkits 1.5.0	C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)CO)O)O)O)O)O

Formula

C15 H24 N2 O17 P2

Name

GALACTOSE-URIDINE-5'-DIPHOSPHATE;
UDP-D-GALACTOPYRANOSE

PDB chain

4lw3 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4lw3 Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	P82 F83 R84 R86 F121 R123 D145 V146 D147 Y177 G185 W207 G208 E210 N211 H241 H243 R250
Binding residue (residue number reindexed from 1)	P13 F14 R15 R17 F52 R54 D76 V77 D78 Y108 G116 W138 G139 E141 N142 H172 H174 R181
Annotation score	4

Catalytic site (original residue number in PDB)	D145 D147 W207 E210 N211 T238 H241 H243
Catalytic site (residue number reindexed from 1)	D76 D78 W138 E141 N142 T169 H172 H174
Enzyme Commision number	2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.

	Molecular Function
GO:0016757	glycosyltransferase activity

	Biological Process
GO:0005975	carbohydrate metabolic process

PDB	RCSB:4lw3, PDBe:4lw3, PDBj:4lw3
PDBsum	4lw3
PubMed	24052259
UniProt	Q9VBZ9\|B4GT7_DROME Beta-1,4-galactosyltransferase 7 (Gene Name=beta4GalT7)

[Back to BioLiP]

Structure of PDB 4lw3 Chain A Binding Site BS02