Structure of PDB 4lt5 Chain A Binding Site BS02

Receptor Information
>4lt5 Chain A (length=265) Species: 5762 (Naegleria gruberi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDGS
VELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVTA
DLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNNC
LYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLELT
DKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPYY
EDTQKNSLKIHKETK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4lt5 Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Resolution2.893 Å
Binding residue
(original residue number in PDB)		Y141 L145 N147 Y153 T155 A156 R224 D231 D234 V293 F295 H297 Q310 K311
Binding residue
(residue number reindexed from 1)		Y85 L89 N91 Y97 T99 A100 R168 D175 D178 V237 F239 H241 Q254 K255
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005506 iron ion binding
GO:0010385 double-stranded methylated DNA binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070579 5-methylcytosine dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:4lt5, PDBe:4lt5, PDBj:4lt5
PDBsum4lt5
PubMed24390346
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

[Back to BioLiP]