Structure of PDB 4lby Chain A Binding Site BS02

Receptor Information

>4lby Chain A (length=401) Species: 274 (Thermus thermophilus)

FVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAP
EERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAIL
VVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEV
RDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLD
AIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVE
IVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERGQVL
AKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQ
LPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKIL
E

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4lby Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4lby Identifying ligand-binding hot spots in proteins using brominated fragments.
• Resolution: 2.692 Å
• Binding residue (original residue number in PDB): T25 T62
• Binding residue (residue number reindexed from 1): T21 T58
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D21 K24 T25 T62 H85
• Catalytic site (residue number reindexed from 1): D17 K20 T21 T58 H81

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4lby, PDBe:4lby, PDBj:4lby
• PDBsum: 4lby
• PubMed: 23989163
• UniProt: P60338|EFTU1_THETH Elongation factor Tu-A (Gene Name=tufA)