Structure of PDB 4kyw Chain A Binding Site BS02

Receptor Information
>4kyw Chain A (length=254) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MELHFNLELVETYKSNSQKARILTEDWVYRQSYCPNCGNNPLNHFENNRP
VADFYCNHCSEEFELKSKKGNFSSTINDGAYATMMKRVQADNNPNFFFLT
YTKNFEVNNFLVLPKQFVTPKSIIQRKPLAPTANRAGWIGCNIDLSQVPS
KGRIFLVQDGQVRDPEKVTKEFKQGLFLRKSSLSSRGWTIEILNCIDKIE
GSEFTLEDMYRFESDLKNIFVKNNHIKEKIRQQLQILRDKEIIEFKGRGK
YRKL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4kyw Structural basis of the methylation specificity of R.DpnI.
Resolution2.35 Å
Binding residue
(original residue number in PDB)
Y13 K14 S15 Q18 R21 N47 N48 R126 L129 A130 N134
Binding residue
(residue number reindexed from 1)
Y13 K14 S15 Q18 R21 N47 N48 R126 L129 A130 N134
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4kyw, PDBe:4kyw, PDBj:4kyw
PDBsum4kyw
PubMed24966351
UniProtP0A459|T2D1_STRPN Type II methyl-directed restriction enzyme DpnI (Gene Name=dpnC)

[Back to BioLiP]