Structure of PDB 4kva Chain A Binding Site BS02

Receptor Information
>4kva Chain A (length=246) Species: 6183 (Schistosoma mansoni) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FVFNILCVGETGIGKSTLLETLFNQKFDFPKLKAVTYDLKKLKLTVVETC
GYGDENNIKPVVDYIDNQFENYLQEELKMKRSMQAFHDTRVHVCLYFIAP
TGHSLKSIDLVAMKKLENKVNVIPVIAKSDTITKSELQKFKARILSEIQS
NEIGIYQFPTDDEAVSETNSVMNQHIPFAVVGSSEEVKTVRVRQYPWGSV
QVENENHCDFVRLREMLLRVNMEDLRERTHGVHYETYRRQRLIEMG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4kva Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4kva Crystal Structure of a Schistosoma mansoni Septin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide.
Resolution2.14 Å
Binding residue
(original residue number in PDB)		S55 E100
Binding residue
(residue number reindexed from 1)		S16 E48
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0051260 protein homooligomerization
GO:0061640 cytoskeleton-dependent cytokinesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005940 septin ring
GO:0015630 microtubule cytoskeleton
GO:0031105 septin complex
GO:0031982 vesicle
GO:0032153 cell division site

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kva, PDBe:4kva, PDBj:4kva
PDBsum4kva
PubMed24464615
UniProtA0A3Q0KDV9|SEP10_SCHMA Septin-10 (Gene Name=SEPT10)

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