Structure of PDB 4kjd Chain A Binding Site BS02

Receptor Information
>4kjd Chain A (length=408) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATR
ILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGV
KANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQH
ASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGG
RKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQL
MQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNP
QGFYLFVEGGRIDQGHTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITA
DHSHVTLRHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTD
CGLAPPAD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4kjd Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4kjd Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
Resolution2.21 Å
Binding residue
(original residue number in PDB)		E216 F269 E270 D285
Binding residue
(residue number reindexed from 1)		E213 F266 E267 D282
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D42 S92 H153 S155 R166 E311 D316 Q317 D357 H358 H432
Catalytic site (residue number reindexed from 1) D39 S89 H150 S152 R163 E308 D313 Q314 D351 H352 H359
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0002020 protease binding
GO:0004035 alkaline phosphatase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0016311 dephosphorylation
GO:0071773 cellular response to BMP stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kjd, PDBe:4kjd, PDBj:4kjd
PDBsum4kjd
PubMed24076154
UniProtP15693|PPBI1_RAT Intestinal-type alkaline phosphatase 1 (Gene Name=Alpi)

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