Structure of PDB 4ki4 Chain A Binding Site BS02

Receptor Information
>4ki4 Chain A (length=898) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNVGKL
KYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYYAKI
QIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPIPNR
YKYVMSFDLTSFYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERPSDV
YSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIKEAL
HNPNLSVDEPLDVDYRFDFSDEIKEKIKKLSAKSLNEMLFRAQRTEVAGM
TAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNE
YLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDK
FARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWT
GKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRML
QEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPF
HIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTE
ITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLFDMF
Ligand information
Receptor-Ligand Complex Structure
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PDB4ki4 Structure-function analysis of ribonucleotide bypass by B family DNA replicases.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		N284 D621 K706 Y708 M728 G729 S735 S783 S784 N786 Y791 K800 H804
Binding residue
(residue number reindexed from 1)		N281 D618 K703 Y705 M725 G726 S732 S780 S781 N783 Y788 K797 H801
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ki4, PDBe:4ki4, PDBj:4ki4
PDBsum4ki4
PubMed24082122
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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