Structure of PDB 4kb6 Chain A Binding Site BS02
Receptor Information
>4kb6 Chain A (length=353) Species:
9823
(Sus scrofa) [
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GAWKLQTVLEKVRLSRHEISEAAEVVNWVVEHLLRRLQGGESEFKGVALL
RTGSYYERVKISAPNQFNVMFKLEVPRIQLEEYCNSGAHYFVKFPLEQFL
EKEILSASKMLSKFRKIIKEEIKNIEDTGVTVERKRRGSPAVTLLISKPK
EISVDIILALESKSSWPASTQKGLPISQWLGAKVKNNLKRQPFYLVPKHA
KGFQEETWRLSFSHIEKDILKNHGQSKTCCEIDGVKCCRKECLKLMKYLL
EQLKKKFGNRRELAKFCSYHVKTAFFHVCTQDPHDNQWHLKNLECCFDNC
VAYFLQCLKTEQLANYFIPGVNLFSRDLIDKPSKEFLSKQIEYERNNGFP
VFW
Ligand information
>4kb6 Chain C (length=13) [
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gacgctagcgtcg
Receptor-Ligand Complex Structure
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PDB
4kb6
Structural mechanism of cytosolic DNA sensing by cGAS.
Resolution
3.0754 Å
Binding residue
(original residue number in PDB)
R150 S154 R185 Y189 K361
Binding residue
(residue number reindexed from 1)
R16 S20 R51 Y55 K217
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4kb6
,
PDBe:4kb6
,
PDBj:4kb6
PDBsum
4kb6
PubMed
23722159
UniProt
I3LM39
|CGAS_PIG Cyclic GMP-AMP synthase (Gene Name=CGAS)
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