Structure of PDB 4k9b Chain A Binding Site BS02
Receptor Information
>4k9b Chain A (length=355) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRGNPLSHF
LEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNP
EEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKN
AKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLM
KYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDK
LLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGF
PIFDK
Ligand information
>4k9b Chain E (length=14) [
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cgtcttcggcaatt
Receptor-Ligand Complex Structure
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PDB
4k9b
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
2.26 Å
Binding residue
(original residue number in PDB)
S165 N196 Y200 Y201 K372
Binding residue
(residue number reindexed from 1)
S17 N48 Y52 Y53 K221
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k9b
,
PDBe:4k9b
,
PDBj:4k9b
PDBsum
4k9b
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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