Structure of PDB 4k99 Chain A Binding Site BS02
Receptor Information
>4k99 Chain A (length=354) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKGNPLSHFL
EGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPE
EISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNA
KDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMK
YLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKL
LAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFP
IFDK
Ligand information
>4k99 Chain E (length=14) [
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cgtcttcggcaatt
Receptor-Ligand Complex Structure
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PDB
4k99
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
1.95 Å
Binding residue
(original residue number in PDB)
R161 S165 A168 N196 Y200 K372
Binding residue
(residue number reindexed from 1)
R13 S17 A20 N48 Y52 K220
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k99
,
PDBe:4k99
,
PDBj:4k99
PDBsum
4k99
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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