Structure of PDB 4k97 Chain A Binding Site BS02
Receptor Information
>4k97 Chain A (length=351) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKD
GNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYL
LEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLA
FFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIF
D
Ligand information
>4k97 Chain E (length=14) [
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cgtcttcggcaatt
Receptor-Ligand Complex Structure
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PDB
4k97
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Resolution
2.41 Å
Binding residue
(original residue number in PDB)
R161 S165 N196 Y200 K372
Binding residue
(residue number reindexed from 1)
R13 S17 N48 Y52 K218
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:4k97
,
PDBe:4k97
,
PDBj:4k97
PDBsum
4k97
PubMed
23647843
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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