Structure of PDB 4k33 Chain A Binding Site BS02

Receptor Information

>4k33 Chain A (length=293) Species: 9606 (Homo sapiens)

LPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVK
MLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYA
AKGNLREFLRARRPPGLDYSFDTSEQLTFKDLVSCAYQVARGMEYLASQK
CIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMA
PEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHR
MDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4k33 Chain A Residue 802

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4k33 Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation.
• Resolution: 2.3405 Å
• Binding residue (original residue number in PDB): N622 D635
• Binding residue (residue number reindexed from 1): N160 D173
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D617 A619 R621 N622 D635 R655
• Catalytic site (residue number reindexed from 1): D155 A157 R159 N160 D173 R193
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:4k33, PDBe:4k33, PDBj:4k33
• PDBsum: 4k33
• PubMed: 23972473
• UniProt: P22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)