Structure of PDB 4juo Chain A Binding Site BS02

Receptor Information
>4juo Chain A (length=479) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDS
NTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMH
GNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEP
TVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKID
KLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIEKLKGGKE
QIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIEL
KKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVIVPILSSYIAHR
REVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKE
NLKVSYDFTEEQAEAIVTLQLYRLTNDVVVLQEEEAELREKIAMLAAIIG
DERTMYNLMKKELREVKKKFTPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4juo Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
Resolution6.53 Å
Binding residue
(original residue number in PDB)		R117 Y118 I170 S171 G173 Y174 A175 N326
Binding residue
(residue number reindexed from 1)		R115 Y116 I168 S169 G171 Y172 A173 N324
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4juo, PDBe:4juo, PDBj:4juo
PDBsum4juo
PubMed23965305
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC)

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