Structure of PDB 4js1 Chain A Binding Site BS02
Receptor Information
>4js1 Chain A (length=318) Species:
9606
(Homo sapiens) [
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PEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAE
ALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVS
SAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVT
TEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLH
PNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQV
DIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDE
DIYLLGKATLPGFRTIHC
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
4js1 Chain A Residue 511 [
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Receptor-Ligand Complex Structure
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PDB
4js1
The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.
Resolution
2.09 Å
Binding residue
(original residue number in PDB)
N212 S322 S323 H370
Binding residue
(residue number reindexed from 1)
N124 S234 S235 H282
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
P320 H370
Catalytic site (residue number reindexed from 1)
P232 H282
Enzyme Commision number
2.4.3.1
: beta-galactoside alpha-(2,6)-sialyltransferase.
Gene Ontology
Molecular Function
GO:0008373
sialyltransferase activity
Biological Process
GO:0006486
protein glycosylation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:4js1
,
PDBe:4js1
,
PDBj:4js1
PDBsum
4js1
PubMed
23999306
UniProt
P15907
|SIAT1_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 1 (Gene Name=ST6GAL1)
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