Structure of PDB 4js1 Chain A Binding Site BS02

Receptor Information
>4js1 Chain A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAE
ALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVS
SAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVT
TEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLH
PNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQV
DIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDE
DIYLLGKATLPGFRTIHC
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain4js1 Chain A Residue 511 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4js1 The structure of human alpha-2,6-sialyltransferase reveals the binding mode of complex glycans.
Resolution2.09 Å
Binding residue
(original residue number in PDB)
N212 S322 S323 H370
Binding residue
(residue number reindexed from 1)
N124 S234 S235 H282
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) P320 H370
Catalytic site (residue number reindexed from 1) P232 H282
Enzyme Commision number 2.4.3.1: beta-galactoside alpha-(2,6)-sialyltransferase.
Gene Ontology
Molecular Function
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation

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Molecular Function

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Biological Process
External links
PDB RCSB:4js1, PDBe:4js1, PDBj:4js1
PDBsum4js1
PubMed23999306
UniProtP15907|SIAT1_HUMAN Beta-galactoside alpha-2,6-sialyltransferase 1 (Gene Name=ST6GAL1)

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