Structure of PDB 4jom Chain A Binding Site BS02

Receptor Information
>4jom Chain A (length=909) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPRFVHLHVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDHTNLCGLVK
FYGAGHGAGIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLIS
KAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVD
ECVAFYEEHFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDV
HFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRSEEEMCELFAD
IPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEE
RLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSK
DNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDF
DVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHP
YGFVDRISKLIPPDPGMTLAKAFEAEPQLPEIYEADEEVKALIDMARKLE
GVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLV
KFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQR
SETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFI
DRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTL
GGADMLRRAMGKKKPEEMAKQRSVFAEGAEKNGINAELAMKIFDLVEKFA
GYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGLVD
ECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEA
RNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMNSL
GDALKAADQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4jom Chain A Residue 1005 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4jom A structural role for the PHP domain in E. coli DNA polymerase III.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H10 H12 D69
Binding residue
(residue number reindexed from 1)		H8 H10 D67
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jom, PDBe:4jom, PDBj:4jom
PDBsum4jom
PubMed23672456
UniProtP10443|DPO3A_ECOLI DNA polymerase III subunit alpha (Gene Name=dnaE)

[Back to BioLiP]