Structure of PDB 4jo0 Chain A Binding Site BS02

Receptor Information
>4jo0 Chain A (length=522) Species: 54571 (Streptomyces venezuelae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMRYSLRQDIAVEPVIAGWYGWSYLLPPQTLARFVHNRFNRIVESYLDD
PQVHAAAVRQRRMHGGPWIHAHEHRDAIEAWYRETAPRRERLDELFEAVR
RLEEDILPRHHGECLDPVYQELPAALAGRVEVFYGRDNRTADYRFVEPLM
YASEYYDESWQQVRFRPVTEDAREFALTTPMLEYGPEQLLVNVPLNSPLL
DAVFRGGLTGTELDDLAARFGLDGERAARFASYFEPTPEEDVLEYVGHAC
VFARHRGTTFLVDPVLSYSGYPGGAENRFTFADLPERIDHLLITHNHQDH
MLFETLLRIRHRVGRVLVPKSTNASLVDPGLGGILRRLGFTDVVEVDDLE
TLSCGSAEVVALPFLGEHGDLRIRSKTGWLIRFGERSVLFAADSTNISPT
MYTKVAEVIGPVDTVFIGMESIGAAASWIYGPLYGEPLDRRTDQSRRLNG
SNFPQAREIVDALEPDEVYVYAMGLEPWMGVVMAVDYDESHPAIVDSDLL
VRHVQDKGGTAERLHLRRTLRL
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4jo0 Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4jo0 Structure of a Dinuclear Iron Cluster-Containing beta-Hydroxylase Active in Antibiotic Biosynthesis.
Resolution2.17 Å
Binding residue
(original residue number in PDB)		D309 H310 D403
Binding residue
(residue number reindexed from 1)		D299 H300 D393
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.99.65: 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jo0, PDBe:4jo0, PDBj:4jo0
PDBsum4jo0
PubMed23980641
UniProtF2RB80|CMLA_STRVP 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase (Gene Name=cmlA)

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