Structure of PDB 4jhv Chain A Binding Site BS02

Receptor Information
>4jhv Chain A (length=496) Species: 195176 (Cerrena caperata) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIGPVTDLTISDGPVSPDGFTRQAILVNNQFPSPLITGNKGDRFQLNVID
NMNNHTMLKSTSIHWHGFFQHGTNWADGPAFVNQCPISPGHSFLYDFQVP
DQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKDLYDVDDDSTVITLAD
WYHLAAKVGPAVPTADATLINGLGRSISTLNADLAVISVTKGKRYRFRLV
SLSCDPNHTFSIDGHTMTVIEADSVNLKPQVVDSIQIFAAQRYSFVLNAD
QDIGNYWIRAMPNSGTRNFDGGVNSAILRYDGADPVEPTTTQTPSSQPLV
ESALTTLEGTAAPGSPTAGGVDLAINMAFGFAGGRFTINGASFTPPTVPV
LLQILSGAQNAQDLLPTGSVYSLPANADIEISLPATAAAPGFPHPFHLHG
HTFAVVRSAGSSTYNYANPVYRDVVSTGSPGDNVTIRFRTDNPGPWFLHC
HIDFHLEAGFAVVMAEDIPDVAAVNPVPQAWSDLCPTYNALDPNDQ
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain4jhv Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4jhv Elucidation of the crystal structure of Coriolopsis caperata laccase: restoration of the structure and activity of the native enzyme from the T2-depleted form by copper ions.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H66 H109 H451
Binding residue
(residue number reindexed from 1)		H66 H109 H451
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H64 H66 H109 H111 H394 H397 H399 H449 C450 H451 I452 H455 F460
Catalytic site (residue number reindexed from 1) H64 H66 H109 H111 H394 H397 H399 H449 C450 H451 I452 H455 F460
Enzyme Commision number 1.10.3.2: laccase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052716 hydroquinone:oxygen oxidoreductase activity
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4jhv, PDBe:4jhv, PDBj:4jhv
PDBsum4jhv
PubMed25849396
UniProtM1GME7

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