Structure of PDB 4j9s Chain A Binding Site BS02

Receptor Information
>4j9s Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEV
MEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEG
LPQGTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4j9s Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		R61 K224 S257 G259 G260 K261 L262 R377 L381 R382
Binding residue
(residue number reindexed from 1)		R62 K219 S252 G254 G255 K256 L257 R372 L376 R377
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4j9s, PDBe:4j9s, PDBj:4j9s
PDBsum4j9s
PubMed23630267
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

[Back to BioLiP]