Structure of PDB 4j9r Chain A Binding Site BS02

Receptor Information
>4j9r Chain A (length=423) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4j9r Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		S113 D115 E116 K224 S257 G259 G260 K261 L262 R377 R382 C384
Binding residue
(residue number reindexed from 1)		S111 D113 E114 K218 S251 G253 G254 K255 L256 R371 R376 C378
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4j9r, PDBe:4j9r, PDBj:4j9r
PDBsum4j9r
PubMed23630267
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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