Structure of PDB 4j9o Chain A Binding Site BS02

Receptor Information
>4j9o Chain A (length=418) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSY
EARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
MSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQ
GPTVQKEGMRKQGLFQWLDSLNLTSPDLQLTVGAVIVEEMRAAIERETGF
QCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG
KLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPV
KPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSE
WSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4j9o Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Resolution2.597 Å
Binding residue
(original residue number in PDB)		K224 S257 G259 K261 L262 R382
Binding residue
(residue number reindexed from 1)		K214 S247 G249 K251 L252 R372
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4j9o, PDBe:4j9o, PDBj:4j9o
PDBsum4j9o
PubMed23630267
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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