Structure of PDB 4isq Chain A Binding Site BS02

Receptor Information

>4isq Chain A (length=414) Species: 1491 (Clostridium botulinum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SINDSKILSLQNKKNTLMDTSGYNAEVRVEGNVQLNPIFPFDFKLGSSGD
DRGKVIVTQNENIVYNAMYESFSISFWIRINKWVSNLPGYTIIDSVKNNS
GWSIGIISNFLVFTLKQNENSEQDINFSYDISKNAAGYNKWFFVTITTNM
MGNMMIYINGKLIDTIKVKELTGINFSKTITFQMNKIPNDNINMWIRDFY
IFAKELDDKDINILFNSLQYTNVVKDYWGNDLRYDKEYYMINVNYMNRYM
SKKGNGIVFNTRKNNNDFNEGYKIIIKRIRGNTNDTRVRGENVLYFNTTI
DNKQYSLGMYKPSRNLGTDLVPLGALDQPMDEIRKYGSFIIQPCNTFDYY
ASQLFLSSNATTNRLGILSIGSYSFKLGDDYWFNHEYLIPVIKIEHYASL
LESTSTHWVFVPAS

Ligand information

>4isq Chain F (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KEDAFSKLKEKFMNE

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4isq Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	M1179 Y1180 K1181 P1182 R1184 N1185 V1191 Y1206 R1234 L1235 E1265
Binding residue (residue number reindexed from 1)	M309 Y310 K311 P312 R314 N315 V321 Y336 R364 L365 E395

Enzymatic activity

Catalytic site (original residue number in PDB)	K906 I969
Catalytic site (residue number reindexed from 1)	K44 I107
Enzyme Commision number	?

Gene Ontology

	Cellular Component
GO:0005576	extracellular region

View graph for
Cellular Component

External links

PDB	RCSB:4isq, PDBe:4isq, PDBj:4isq
PDBsum	4isq
PubMed	23932591
UniProt	Q9LBR1

[Back to BioLiP]