Structure of PDB 4iqx Chain A Binding Site BS02

Receptor Information

>4iqx Chain A (length=476) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDSRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRSMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALAHH

Ligand information

>4iqx Chain C (length=5)

ggccc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4iqx A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): Y336 D338 D339 L386 K387 I411 R416 K423 S426
• Binding residue (residue number reindexed from 1): Y336 D338 D339 L386 K387 I411 R416 K423 S426

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4iqx, PDBe:4iqx, PDBj:4iqx
• PDBsum: 4iqx
• PubMed: 20865120
• UniProt: Q9QCE4