Structure of PDB 4ii9 Chain A Binding Site BS02

Receptor Information

>4ii9 Chain A (length=337) Species: 1629 (Weissella viridescens)

PVLNLNDPQAVERYEEFMRQSPYGQVTQDLGWAKVKNNWEPVDVYLEDDQ
GAIIAAMSMLLGDTPTDKKFAYASKGPVMDVTDVDLLDRLVDEAVKALDG
RAYVLRFDPEVAYSDEFNTTLQDHGYVTRNRNVADAGMHATIQPRLNMVL
DLTKFPDAKTTLDLYPSKTKSKIKRPFRDGVEVHSGNSATELDEFFKTYT
TMAERHGITHRPIEYFQRMQAAFDADTMRIFVAEREGKLLSTGIALKYGR
KIWYMYAGSMDGNTYYAPYAVQSEMIQWALDTNTDLYDLGGIESESTDDS
LYVFKHVFVKDAPREYIGEIDKVLDPEVYAELVKDGH

Ligand information

>4ii9 Chain C (length=3)

cca

...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ii9 The Structure of FemXWv in Complex with a Peptidyl-RNA Conjugate: Mechanism of Aminoacyl Transfer from Ala-tRNA(Ala) to Peptidoglycan Precursors
• Resolution: 1.66 Å
• Binding residue (original residue number in PDB): M202 H206 A257 S259 P268 G291 S300 K305
• Binding residue (residue number reindexed from 1): M202 H206 A257 S259 P268 G291 S300 K305

Enzymatic activity

• Catalytic site (original residue number in PDB): K36 D108 R211 F304 K305 E319
• Catalytic site (residue number reindexed from 1): K36 D108 R211 F304 K305 E319
• Enzyme Commision number: 2.3.2.10: UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase.

Gene Ontology

Molecular Function

• GO:0016746 acyltransferase activity
• GO:0016755 aminoacyltransferase activity
• GO:0047206 UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity

Biological Process

• GO:0008360 regulation of cell shape
• GO:0009252 peptidoglycan biosynthetic process
• GO:0044038 cell wall macromolecule biosynthetic process
• GO:0071555 cell wall organization

External links

• PDB: RCSB:4ii9, PDBe:4ii9, PDBj:4ii9
• PDBsum: 4ii9
• PubMed: 23744707
• UniProt: Q9EY50|FEMX_WEIVI UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase (Gene Name=femX)