Structure of PDB 4i5k Chain A Binding Site BS02

Receptor Information
>4i5k Chain A (length=266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFH
SRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQIT
DYFSYEHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSG
AVTKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELE
YFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMA
HIFYDTFFNLEKYLDH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4i5k Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4i5k Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D364 D366 D368 V370 E375
Binding residue
(residue number reindexed from 1)		D187 D189 D191 V193 E198
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4i5k, PDBe:4i5k, PDBj:4i5k
PDBsum4i5k
PubMed23752926
UniProtQ06190|P2R3A_HUMAN Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (Gene Name=PPP2R3A)

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