Structure of PDB 4hno Chain A Binding Site BS02

Receptor Information
>4hno Chain A (length=285) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIKIGAHMPISKGFDRVPQDTVNIGGNSFQIFPHNARSWSAKLPSDEAAT
KFKREMKKHGIDWENAFCHSGYLINLASPKDDIWQKSVELLKKEVEICRK
LGIRYLNIHPGSHLGTGEEEGIDRIVRGLNEVLNNTEGVVILLENVSQKG
GNIGYKLEQLKKIRDLVDQRDRVAITYDTCHGFDSGYDITKKEGVEALLN
EIESLFGLERLKMIHLNDSKYPLGAAKDRHERIGSGFIGEEGFAVFFSFK
EIQEVPWILETPGGNEEHAEDIKKVFEIIEKFGIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4hno Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4hno Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes.
Resolution0.9194 Å
Binding residue
(original residue number in PDB)		H181 D228 H230
Binding residue
(residue number reindexed from 1)		H181 D228 H230
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) R37 H69 Y72 H109 E144 D178 H181 H215 D228 H230 E260
Catalytic site (residue number reindexed from 1) R37 H69 Y72 H109 E144 D178 H181 H215 D228 H230 E260
Enzyme Commision number 3.1.21.2: deoxyribonuclease IV.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 endonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008270 zinc ion binding
GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4hno, PDBe:4hno, PDBj:4hno
PDBsum4hno
PubMed23355472
UniProtQ9WYJ7|END4_THEMA Probable endonuclease 4 (Gene Name=nfo)

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