Structure of PDB 4hkq Chain A Binding Site BS02

Receptor Information
>4hkq Chain A (length=441) Species: 373193 (Xenotropic MuLV-related virus VP62) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPH
IQRLLDQGILVPCQSPWNTPLLPVKKDYRPVQDLREVNKRVEDIHPTVPN
PYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDQLTWTRL
PQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSEQDCQR
GTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETV
MGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTLFNWGPDQ
QKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRR
PVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAV
EALVKQPPARMTHYQAMLLDTDRVQFGPVVALNPATLLPLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hkq Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
Resolution3.04 Å
Binding residue
(original residue number in PDB)		Y222 D224 L269 R284 R298 R301 E302 G305 T306 F309 V402
Binding residue
(residue number reindexed from 1)		Y184 D186 L231 R246 R260 R263 E264 G267 T268 F271 V362
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4hkq, PDBe:4hkq, PDBj:4hkq
PDBsum4hkq
PubMed23382176
UniProtA1Z651|POL_XMRV6 Gag-Pol polyprotein (Gene Name=gag-pol)

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