Structure of PDB 4hi6 Chain A Binding Site BS02

Receptor Information

>4hi6 Chain A (length=138) Species: 12455 (Borna disease virus)

HSYVELKDKVIVPGWPTLMLEIDFVGGTSRNQFLNIPFLSVKEPLQLPRE
KKLTDYFTIDVEPAGHSLVNIYFQIDDFLLLTLNSLSVYKDPIRKYMFLR
LNKEQSKWAINAAFNVFSYRLRNIGVGPLGPDIRSSGP

Ligand information

• Ligand ID: 3GP
• InChI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-5(17)6(3(1-16)22-9)23-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
• InChIKey: ZDPUTNZENXVHJC-UUOKFMHZSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: c1nc2c(n1C3C(C(C(O3)CO)OP(=O)(O)O)O)N=C(NC2=O)N
  CACTVS 3.341: NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO)[CH](O[P](O)(O)=O)[CH]3O
  OpenEye OEToolkits 1.5.0: c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)(O)O)O)N=C(NC2=O)N
  CACTVS 3.341: NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO)[C@@H](O[P](O)(O)=O)[C@H]3O
  ACDLabs 10.04: O=C1c2ncn(c2N=C(N)N1)C3OC(C(OP(=O)(O)O)C3O)CO
• Formula: C10 H14 N5 O8 P
• Name: GUANOSINE-3'-MONOPHOSPHATE
• DrugBank: DB03315
• ZINC: ZINC000004807333
• PDB chain: 4hi6 Chain B Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4hi6 Matrix protein variants provide support for alternative Borna disease virus infection pathway
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): G129 V130 G131
• Binding residue (residue number reindexed from 1): G125 V126 G127
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0039660 structural constituent of virion
• GO:0042802 identical protein binding

Cellular Component

• GO:0016020 membrane
• GO:0020002 host cell plasma membrane
• GO:0030430 host cell cytoplasm
• GO:0044423 virion component

External links

• PDB: RCSB:4hi6, PDBe:4hi6, PDBj:4hi6
• PDBsum: 4hi6
• UniProt: P0C794|MATRX_BDV1 Matrix protein (Gene Name=M)