Structure of PDB 4hcb Chain A Binding Site BS02

Receptor Information

>4hcb Chain A (length=462) Species: 668369 (Escherichia coli DH5[alpha])

QQSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADD
YLPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVR
FDDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPE
NLPSFRLEHLTKANGIEDAMADVYATIAMAKLVKTRQPRLFDYLFTHRNK
HKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMVDL
AGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQANT
LRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAEPFTPSDNVD
AQLYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARN
FPGTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALL
KALWQYADEIVH

Ligand information

>4hcb Chain D (length=12)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 4hcb The structures of Escherichia coli exonuclease I in complex with the single strand DNA
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): H215 K216 M218
• Binding residue (residue number reindexed from 1): H201 K202 M204

Enzymatic activity

• Enzyme Commision number: 3.1.11.1: exodeoxyribonuclease I.

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0000287 magnesium ion binding
• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003697 single-stranded DNA binding
• GO:0004527 exonuclease activity
• GO:0004529 DNA exonuclease activity
• GO:0005515 protein binding
• GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
• GO:0046872 metal ion binding
• GO:0051575 5'-deoxyribose-5-phosphate lyase activity

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006274 DNA replication termination
• GO:0006281 DNA repair
• GO:0006308 DNA catabolic process

External links

• PDB: RCSB:4hcb, PDBe:4hcb, PDBj:4hcb
• PDBsum: 4hcb
• UniProt: P04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)