Structure of PDB 4hca Chain A Binding Site BS02

Receptor Information
>4hca Chain A (length=99) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPTSCAN
CQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKM
Ligand information
Receptor-Ligand Complex Structure
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PDB4hca DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R276 R277 Y283 N340 L344 R353 M357 K359 T364 R365 R367
Binding residue
(residue number reindexed from 1)		R17 R18 Y24 N70 L74 R83 M87 K89 T94 R95 R97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:4hca, PDBe:4hca, PDBj:4hca
PDBsum4hca
PubMed23142663
UniProtP23771|GATA3_HUMAN Trans-acting T-cell-specific transcription factor GATA-3 (Gene Name=GATA3)

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