Structure of PDB 4h9g Chain A Binding Site BS02

Receptor Information

>4h9g Chain A (length=404) Species: 274 (Thermus thermophilus)

KGEFVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDID
KAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDG
AILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVE
MEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWE
LLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGD
EVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERG
QVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTG
VVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVT
KILE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4h9g Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4h9g Identifying ligand-binding hot spots in proteins using brominated fragments.
• Resolution: 1.93 Å
• Binding residue (original residue number in PDB): T25 T62
• Binding residue (residue number reindexed from 1): T24 T61
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D21 K24 T25 T62 H85
• Catalytic site (residue number reindexed from 1): D20 K23 T24 T61 H84
• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4h9g, PDBe:4h9g, PDBj:4h9g
• PDBsum: 4h9g
• PubMed: 23989163
• UniProt: P60338|EFTU1_THETH Elongation factor Tu-A (Gene Name=tufA)