Structure of PDB 4h7o Chain A Binding Site BS02

Receptor Information

>4h7o Chain A (length=258) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961)

AHTKVWQTIVAEAREQAEQEPMLASFYHATIIKHDSLKAALSYILANRLN
TASMPAMAVREVIEEAFAADPSISEAAACDICATVNRDPAVSMYSMPLLY
LKGYHALQGYRVANWLWRQGRKALATYFQNQISVACQVDIHPAARIGRGI
MLDHATGIVIGETAVVEDDVSILQDVTLGGTGKECGDRHPKIREGVMIGA
GAKILGNIEVGEGAKIGSGSVVLQAVPPHTTVAGVPARIVGRPQSDKPSL
DMDQQFNG

Ligand information

• Ligand ID: ARG
• InChI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1
• InChIKey: ODKSFYDXXFIFQN-BYPYZUCNSA-O
• SMILES:
  OpenEye OEToolkits 1.5.0: C(CC(C(=O)O)N)CNC(=[NH2+])N
  CACTVS 3.341: N[C@@H](CCCNC(N)=[NH2+])C(O)=O
  OpenEye OEToolkits 1.5.0: C(C[C@@H](C(=O)O)N)CNC(=[NH2+])N
  CACTVS 3.341: N[CH](CCCNC(N)=[NH2+])C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CCCN\C(=[NH2+])N
• Formula: C6 H15 N4 O2
• Name: ARGININE
• PDB chain: 4h7o Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4h7o Crystal structure of Serine acetyltransferase from Vibrio cholerae O1 biovar El Tor N16961.
• Resolution: 2.17 Å
• Binding residue (original residue number in PDB): T55 S57 Y131 Q135
• Binding residue (residue number reindexed from 1): T51 S53 Y127 Q131
• Annotation score: 2

Enzymatic activity

• Enzyme Commision number: 2.3.1.30: serine O-acetyltransferase.

Gene Ontology

Molecular Function

• GO:0009001 serine O-acetyltransferase activity
• GO:0016740 transferase activity
• GO:0016746 acyltransferase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine
• GO:0008652 amino acid biosynthetic process
• GO:0019344 cysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4h7o, PDBe:4h7o, PDBj:4h7o
• PDBsum: 4h7o
• UniProt: Q9KNT2