Structure of PDB 4h5i Chain A Binding Site BS02

Receptor Information
>4h5i Chain A (length=344) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTVLRVDPT
KDTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGN
KHLRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASS
KVPAIMRIIDPSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVIS
TVTGSCIARKTDFDKNWSLSKINFIADDTVLIAASLKKGKGIVLTKISIK
SGNTSVLRSKQVTNRFKGITSMDVDMKGELAVLASNDNSIALVKLKDLSM
SKIFKQAHSFAITEVTISPDSTYVASVSAANTIHIIKLPLNYAN
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain4h5i Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4h5i The structure of sec12 implicates potassium ion coordination in sar1 activation.
Resolution1.36 Å
Binding residue
(original residue number in PDB)		Y137 D178 L179 H180 I222 N223
Binding residue
(residue number reindexed from 1)		Y137 D178 L179 H180 I222 N223
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:4h5i, PDBe:4h5i, PDBj:4h5i
PDBsum4h5i
PubMed23109340
UniProtP11655|SEC12_YEAST Guanine nucleotide-exchange factor SEC12 (Gene Name=SEC12)

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